Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope
Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiaohua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dong Meng, Molin Huang, Zongyi Yi, , Dali Li
This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.
Nature Biotechnology · Jun 3, 2025Peer-reviewedBioengineering