Author

Zongyi Yi

Peking UniversityORCID 0000-0002-5654-4221Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Wensheng WeiiD· 2 shared Changming Luan· 1 shared Chunhui WangiD· 1 shared Dali LiiD· 1 shared Dan ZhangiD· 1 shared Dong MengiD· 1 shared Feng TianiD· 1 shared Gaojie SongiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Wensheng WeiORCID

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2 papers

Recent·Most cited

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope

Liang Chen, Mengjia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiaohua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dong Meng, Molin Huang, Zongyi Yi, , Dali Li

This paper develops eTd-mtABEs, engineered mitochondrial A-to-G base editors with enhanced efficiency and targeting scope, enabling efficient generation of mtDNA disease models in rat embryos.

Nature Biotechnology · Jun 3, 2025Peer-reviewedBioengineering

Leveraging Endogenous ADAR for Programmable Editing on RNA

Liang Qu, Zongyi Yi, Shiyou Zhu, Chunhui Wang, Zhongzheng Cao, Zhuo Long Zhou, Pengfei Yuan, Ying Fang Yu, Feng Tian, Zhiheng Liu, Ying Bao, Yanxia Zhao, Wensheng Wei

This paper introduces LEAPER, a method using endogenous ADAR proteins for targeted RNA editing, demonstrating its efficacy in restoring p53 function and catalytic activity in disease models.

bioRxiv · Apr 19, 2019 · PreprintGenomics