Author

H. M. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biophysics· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Morrissey· 2 shared E. Corey· 2 shared J. E. Berchuck· 2 shared M. L. Freedman· 2 shared N. De Sarkar· 2 shared P. S. Nelson· 2 shared S. Besteiro· 2 shared S. C. Baca· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

C. Morrissey

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Author profile →

9 papers

Recent·Most cited

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

S. G. Sanchez, E. Bassot, A. Cerutti, H. M. Nguyen, A. Aïda, N. Blanchard, S. Besteiro

This study shows that targeting the apicoplast in Toxoplasma gondii bradyzoites reduces their viability, suggesting it as a potential therapeutic target for chronic infections.

bioRxiv · Jan 13, 2023Microbiology

Computational design of peptides to target Nav1.7 channel with high potency and selectivity for the treatment of pain

P. T. Nguyen, H. M. Nguyen, K. M. Wagner, R. Stewart, V. Singh, P. Thapa, Y.-J. Chen, M. W. Lillya, A. T. Ton, R. Kondo, A. Ghetti, M. W. Pennington, B. Hammock, T. N. Griffith, J. T. Sack, , V. Yarov-Yarovoy

The paper designs potent and selective peptide inhibitors of human NaV1.7 channels using Rosetta, with two peptides showing sub-nanomolar IC50 and high selectivity over other sodium channels.

bioRxiv · Jul 21, 2022Biophysics

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

N. De Sarkar, R. D. Patton, A.-L. Doebley, B. Hanratty, A. J. Kreitzman, J. F. Sarthy, M. Ko, M. Adil, S. Brahma, M. P. Meers, D. H. Janssens, L. S. Ang, I. Coleman, A. Bose, R. F. Dumpit, , G. Ha

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

bioRxiv · Jun 21, 2022Cancer Biology

Expansion of tissue-resident CD8+ T cells and CD4+ Th17 cells in the nasal mucosa following mRNA COVID-19 vaccination

A. Ssemaganda, H. M. Nguyen, F. Nuhu, N. Jahan, C. M. Card, S. Kiazyk, G. Severini, Y. Keynan, R.-C. Su, H. Ji, B. Abrenica, P. J. McLaren, B. Ball, J. Bullard, P. Van Caeseele, , L. McKinnon

This study examines changes in nasal T cell populations after mRNA COVID-19 vaccination, finding expansion of CD8+ T cells and CD4+ Th17 cells.

bioRxiv · May 7, 2021 · PreprintImmunology

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

S. C. Baca, D. Y. Takeda, J.-H. Seo, J. Hwang, S. Y. Ku, R. Arafeh, T. Arnoff, S. Agarwal, C. Bell, E. O'Connor, X. Qiu, S. Abu Alaiwi, R. I. Corona, M. A. S. Fonseca, C. Giambartolomei, , M. L. Freedman

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

bioRxiv · Oct 23, 2020Cancer Biology

Copper nanoparticle application enhances plant growth and grain yield in maize under drought stress conditions

C. V. Ha, D. V. Nguyen, H. M. Nguyen, N. T. Le, K. H. Nguyen, H. M. Le, A. T. Nguyen, N. T. T. Dinh, S. A. Hoang

This study shows copper nanoparticle priming improves drought tolerance in maize by enhancing water content, biomass, and protective mechanisms, leading to higher grain yield under drought stress.

bioRxiv · Feb 24, 2020Plant Biology

Direct observation of independently moving replisomes in Escherichia coli

A. Japaridze, C. Gogou, J. W. J. Kerssemakers, H. M. Nguyen, C. Dekker

The paper observes independently moving replisomes in E. coli, supporting the train-track model over the factory model for chromosome replication.

bioRxiv · Aug 13, 2019Cell Biology

Ancient Genomics Reveals Four Prehistoric Migration Waves into Southeast Asia

H. McColl, F. Racimo, L. Vinner, F. Demeter, U. G. Wilken, J. V. Moreno Mayar, A. Seguin-Orlando, C. de la Fuente Castro, S. Wasef, A. Prohaska, A. Margarayan, P. de Barros Damgaard, R. Shoocongdej, V. Souksavatdy, T. Sayavongkhamdy, , R. A Foley

The paper analyzes ancient genomes from Southeast Asia to test migration models, finding support for two major dispersal waves and genetic continuity with Andamanese populations.

bioRxiv · Mar 8, 2018Evolutionary Biology

Characterisation of two Toxoplasma PROPPINs homologous to Atg18/WIPI suggests they have evolved distinct specialised functions

H. M. Nguyen, S. Liu, W. Daher, F. Tan, S. Besteiro

This study characterizes two Toxoplasma PROPPINs homologous to ATG18/WIPI, revealing distinct specialized functions in autophagy-related processes.

bioRxiv · Dec 18, 2017Microbiology