N. Dezorella

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

The Natural Material Evolution and Stage-wise Assembly of Silk Along the Silk Gland

This paper uses imaging to study silk fiber formation in silkworm glands, revealing structural transitions and compartmentalization that enable stable protein assembly and fiber spinning.

Biogenic plate-like guanine crystals form via templated nucleation of thin crystal leaflets on amyloid scaffolds

The paper shows that biogenic plate-like guanine crystals form through templated nucleation on amyloid scaffolds in zebrafish larvae.

Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

This paper identifies kynurenic acid as a protective metabolite that enhances cardiac cell viability and mitochondrial function following ischemic damage.

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.