S. Malitsky

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

A systematic bi-genomic split-GFP assay illuminates the mitochondrial matrix proteome and protein targeting routes

The paper uses a bi-genomic split-GFP assay to identify mitochondrial matrix and inner membrane proteins, revealing 50 previously unvisualized proteins and characterizing dually localized proteins.

Phages reconstitute NAD+ to counter bacterial immunity

This study identifies two phage pathways, NARP1 and NARP2, that reconstitute NAD+ from its degradation products to counter bacterial immunity.

High-energy demand and nutrient exhaustion in MTCH2 knockout cells

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

The Role of Vitamin D in Emiliania huxleyi: A Microalgal Perspective on UV Exposure

This study shows Emiliania huxleyi produces vitamin D2 and D3 in response to UV radiation and regulates protective mechanisms transcriptionally when exposed to vitamin D, enhancing photosynthesis and reducing oxidative stress.

Reducing the Bacterial Lag Phase Through Methylated Compounds: Insights from Algal-Bacterial Interactions

The study shows methylated compounds from microalgae reduce the bacterial lag phase in Phaeobacter inhibens by enabling methionine cycle assimilation.

A conserved family of immune effectors cleaves cellular ATP upon viral infection

This study identifies a conserved family of immune effectors that degrade ATP and dATP during viral infection, halting phage propagation and suggesting a conserved innate immune strategy across life.

Metabolic rewiring of the probiotic bacterium Lacticaseibacillus rhamnosus GG contributes to cell wall remodeling and antimicrobials production

This study shows that fermentation in LGG alters its metabolome, proteome, and cell wall properties, enhancing antimicrobial activity against pathogens.

Novel lipid biomarkers for algal resistance to viral infection in the ocean

The paper identifies novel lipid biomarkers in Emiliania huxleyi that correlate with resistance to viral infection in natural ocean blooms.

Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

This paper identifies kynurenic acid as a protective metabolite that enhances cardiac cell viability and mitochondrial function following ischemic damage.

LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways

This study shows LIS1 regulates mESCs viability and mechanosensitive properties through RNA-binding interactions with AGO2 and other proteins.

A dynamic rhizosphere interplay between tree roots and soil bacteria under drought

The study investigates how drought affects root exudates and microbial interactions in Cupressus saplings, finding increased exudation and maintained phosphorus availability with bacterial inoculation.

Antiviral activity of bacterial TIR domains via signaling molecules that trigger cell death

This study identifies a bacterial antiviral pathway using TIR domains to produce a signaling molecule that triggers cell death via NAD depletion.

Bacterial virulence against an oceanic bloom-forming phytoplankter is mediated by algal DMSP

The paper shows that DMSP from the alga Emiliania huxleyi enhances virulence of the bacterium Sulfitobacter D7, leading to algal bloom demise.