Metabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control
Shon A. Levkovich, Christine Maria Lim, Emi A. Marzini, Hanaa Adsi, Maoz Lahav, Ilana Sogolovsky-Bard, Myra Gartner, Keila Kaplan, Yasmin DeRowe, M. Pasmanik-Chor, Alexander S. Brandis, Michele Vendruscolo, Ehud Gazit, Dana Laor Bar‐Yosef
The paper identifies metabolite-specific failure thresholds in yeast linked to network topology, solubility, and translational control, revealing mechanisms of metabolic toxicity and resilience.
bioRxiv · Apr 2, 2026 · PreprintCell Biology