A. Brandis

The molecular mechanism of on-demand sterol biosynthesis at organelle contact sites

This study identifies Yet3 as a protein that recruits sterol biosynthesis enzymes to ER contact sites, enabling on-demand sterol production and influencing organellar structure and function.

High-energy demand and nutrient exhaustion in MTCH2 knockout cells

This study shows that MTCH2 deletion increases energy demand and metabolic imbalance in cells, which inhibits adipocyte differentiation.

A conserved family of immune effectors cleaves cellular ATP upon viral infection

This study identifies a conserved family of immune effectors that degrade ATP and dATP during viral infection, halting phage propagation and suggesting a conserved innate immune strategy across life.

The differential regulation of placenta trophoblast bisphosphoglycerate mutase in fetal growth restriction: preclinical study in mice and observational histological study of human placenta.

This study investigates the role of placental BPGM in fetal growth restriction using mouse models and human placental analysis, finding altered BPGM expression and 2,3 BPG levels in hypoxic conditions.

Bringing BOS to light: Uncovering the key enzyme in the biosynthesis of the neurotoxin β-ODAP in Grass Pea (Lathyrus sativus L.)

The paper identifies the enzyme BOS responsible for β-ODAP biosynthesis in grass pea, revealing its structure and function after over 50 years of research.

ATP-Citrate lyase fuels axonal transport across species

The paper identifies ATP-citrate lyase (Acly) as a rate-limiting enzyme modulating Atat1 activity and α-tubulin acetylation, linking Elongator to axonal transport in projection neurons across species.