Author

I. Grosheva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:imaging· 2 Organism:mouse· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Geiger· 2 shared A. Asmal· 1 shared A. M. Dowbaj· 1 shared A. Plotnikov· 1 shared A. S. Haka· 1 shared B. Haim· 1 shared C. Ampe· 1 shared E. P. Papapetrou· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

B. Geiger

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multi-site assessment of reproducibility in high-content live cell imaging data

J. Hu, X. Serra-Picamal, G.-J. Bakker, M. V. Troys, S. Winograd-katz, N. Ege, X. Gong, Y. Didan, I. Grosheva, O. Polansky, K. Bakkali, E. V. Hamme, M. v. Erp, M. Vullings, F. Weiss, , S. Stromblad

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

bioRxiv · Nov 18, 2022 · PreprintCell Biology

Rock inhibitors target SRSF2 leukemia by disrupting cell mitosis and nuclear morphology

M. Su, T. Fleisher, I. Grosheva, M. B. Horev, M. Olszewska, B. Haim, A. Plotnikov, S. Carvalho, Y. Moskovitz, M. Minden, N. Chapal-Ilani, E. P. Papapetrou, N. Dezorella, T. Cheng, N. Kaushansky, , L. I. Shlush

This study identifies ROCK inhibitors as effective targeting agents for SRSF2 mutant leukemia by disrupting mitosis and nuclear morphology in vitro and in xenograft models.

bioRxiv · Feb 15, 2022 · PreprintCancer Biology

TLR4-dependent signaling drives extracellular catabolism of low-density lipoprotein aggregates

R. K. Singh, A. S. Haka, A. Asmal, V. C. Barbosa-Lorenzi, I. Grosheva, H. F. Chin, Y. Xiong, T. Hla, F. R. Maxfield

This study shows TLR4 signaling promotes extracellular catabolism of LDL aggregates and lipid accumulation in macrophages through lysosomal synapse formation.

bioRxiv · Apr 15, 2019 · PreprintCell Biology