A. A. Kelvin

Pre-existing immunity to influenza viruses through infection and/or vaccination leads to viral mutational signatures associated with unique immune responses during a subsequent infection

This study shows that host immune history from infection or vaccination influences viral mutation patterns during subsequent influenza infections, with vaccinated mice showing more mutations than preinfected-vaccinated mice.

SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney

This study shows SARS-CoV-2 infection in Syrian hamsters causes inflammation and type I interferon suppression in multiple organs, including the heart and kidney, similar to human COVID-19 symptoms.

Computational assessment of the spike protein antigenicity reveals diversity in B cell epitopes but stability in T cell epitopes across SARS-CoV-2 variants

The paper assesses changes in SARS-CoV-2 spike protein antigenicity across variants, finding diversity in B cell epitopes but stability in T cell epitopes, suggesting T cell-based vaccines may be more durable.

Defective influenza A virus RNA products mediate MAVS-dependent upregulation of human leukocyte antigen class I proteins

This paper shows that defective influenza A virus RNAs trigger MAVS-dependent upregulation of HLA class I proteins, which may aid viral evasion of innate immunity.

Glycomic analysis of host-response reveals high mannose as a key mediator of influenza severity

This study identifies high mannose as a key mediator of influenza severity through glycomic analysis in a ferret model.

Influenza preimmunity increases vaccination efficacy by influencing antibody longevity,neutralization activity, and epitope specificity

This study shows that preimmune hosts have stronger and more effective antibody responses to influenza vaccination, leading to better disease protection compared to naive hosts.