Author

N. J. Spann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

C. K. Glass· 2 shared A. Hammond· 1 shared A. Henke· 1 shared A. Quach· 1 shared A. R. Pessentheiner· 1 shared A. W. T. Chiang· 1 shared B. Ramms· 1 shared C. A. Autran· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

C. K. Glass

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2 papers

Recent·Most cited

The Human Milk Oligosaccharide 3-Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice.

A. R. Pessentheiner, N. J. Spann, C. A. Autran, B. Ramms, A. W. T. Chiang, K. V. Grunddal, Y. Wang, A. Quach, L. M. Booshehri, A. Hammond, C. Tognaccini, J. Latasiewicz, j. L. Witztum, H. M. Hoffman, N. E. Lewis, , P. L. S. M. Gordts

This study shows that 3-sialyllactose reduces inflammation and atherosclerosis in mice by modulating transcriptional activity in macrophages.

bioRxiv · Mar 19, 2021Immunology

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

E. D. Muse, S. Yu, C. R. Edillor, J. Tao, N. J. Spann, T. D. Troutman, J. S. Seidman, A. Henke, J. T. Roland, K. A. Ozeki, J. G. McDonald, J. Bahadorani, S. Tsimikas, T. R. Grossman, M. S. Tremblay, C. K. Glass

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.

bioRxiv · Feb 11, 2018Cell Biology