Author

J. T. Roland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

A. J. Simmons· 2 shared C. L. Sears· 2 shared J. R. Goldenring· 2 shared M. J. Shrubsole· 2 shared N. O. Markham· 2 shared R. J. Coffey· 2 shared A. Henke· 1 shared A. N. Southard-Smith· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. J. Simmons

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Therapy Development for Microvillus Inclusion Disease using Patient-derived Enteroids

M. Kalashyan, K. Raghunathan, H. Oller, M.-T. Bayer, L. Jimenez, J. T. Roland, E. Kolobova, S. J. Hagen, J. D. Goldsmith, M. D. Shub, J. R. Goldenring, I. Kaji, J. R. Thiagarajah

This study uses patient-derived enteroids to model Microvillus Inclusion Disease and identifies therapeutic strategies targeting Notch signaling and chloride channels.

bioRxiv · Jan 28, 2023 · PreprintCell Biology

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

B. Chen, E. T. McKinley, A. J. Simmons, M. A. Ramirez, X. Zhu, A. N. Southard-Smith, N. O. Markham, Q. Sheng, J. Drewes, Y. Xu, C. N. Heiser, Y. Zhou, F. Revetta, L. D. Berry, W. Zheng, , K. Lau

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

bioRxiv · Jan 11, 2021Cancer Biology

Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms

M. C. Macedonia, J. L. Drewes, N. O. Markham, A. J. Simmons, J. T. Roland, P. N. Vega, C. R. Scurrah, R. J. Coffey, M. J. Shrubsole, C. L. Sears, K. S. Lau

This paper introduces a clinically adaptable polymer that preserves spatial compartments of colonic tissues and biofilms for simultaneous analysis.

bioRxiv · Apr 15, 2020Cell Biology

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP pathways in macrophages

E. D. Muse, S. Yu, C. R. Edillor, J. Tao, N. J. Spann, T. D. Troutman, J. S. Seidman, A. Henke, J. T. Roland, K. A. Ozeki, J. G. McDonald, J. Bahadorani, S. Tsimikas, T. R. Grossman, M. S. Tremblay, C. K. Glass

This study shows that desmosterol and its mimetics selectively activate LXR in macrophages without inducing SREBP1c-mediated hypertriglyceridemia, unlike conventional LXR agonists.

bioRxiv · Feb 11, 2018Cell Biology