Author

M. A. Dyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 6

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Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. Stewart· 4 shared A. G. Patel· 3 shared J. Easton· 3 shared M. Pan· 3 shared P. Geeleher· 3 shared B. Freeman· 2 shared B. Gordon· 2 shared H. Sheppard· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

E. Stewart

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6 papers

Recent·Most cited

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

M. Pan, Y. Zhang, W. C. Wright, X. Liu, B. Passaia, D. Currier, R. H. Chapple, J. Steele, J. P. Connelly, M. Lu, H.-M. Lee, A. Loughran, L. Yang, B. J. Abraham, S. M. Pruett-Miller, , P. Geeleher

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

bioRxiv · May 9, 2024Cancer Biology

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

S. G. Danielli, Y. Wei, M. A. Dyer, E. Stewart, M. Wachtel, B. W. Schaefer, A. G. Patel, D. M. Langenau

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

bioRxiv · Oct 13, 2023Cancer Biology

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.

R. H. Chapple, X. Liu, S. Natarajan, M. I. M. Alexander, Y. Kim, A. G. Patel, C. W. LaFlamme, M. Pan, W. C. Wright, H.-M. Lee, Y. Zhang, M. Lu, S. C. Koo, C. Long, J. Harper, , P. Geeleher

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

bioRxiv · Apr 13, 2023Cancer Biology

The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres

M. K. Graham, B. Xu, C. Davis, A. K. Meeker, C. M. Heaphy, S. Yegnasubramanian, M. A. Dyer, M. Zeineldin

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

bioRxiv · May 18, 2022Cancer Biology

The Myogenesis Program Drives Clonal Selection and Drug Resistance in Rhabdomyosarcoma

A. G. Patel, X. Chen, X. Huang, M. R. Clay, N. Komarova, M. J. Krasin, A. Pappo, H. Tillman, B. A. Orr, J. McEvoy, B. Gordon, K. Blankenship, C. Reilly, X. Zhou, J. L. Norrie, , M. A. Dyer

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

bioRxiv · Jun 16, 2021Cancer Biology

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.

M. Pan, C. Wright, R. Chapple, A. Zubair, M. Sandhu, J. Batchelder, J. Low, K. Blankenship, L. Wang, B. Gordon, P. Archer, S. W. Brady, S. Natarajan, M. Pozsgai, J. Schuetz, , P. Geeleher

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

bioRxiv · Feb 25, 2021Cancer Biology