Author

T. W. Herling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:protein folding & dynamics· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Approach:microscopy & imaging analysis· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

G. Krainer· 4 shared M. M. Schneider· 4 shared T. P. J. Knowles· 4 shared Q. A. E. Peter· 3 shared C. M. Dobson· 2 shared F. S. Ruggeri· 2 shared F.-U. Hartl· 2 shared H. Ausserwoeger· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiophysics

G. Krainer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Thermodynamic profiles for co-translational trigger factor function

T. W. Herling, A. M. E. Cassaignau, A. S. Wentink, Q. A. E. Peter, P. C. Kumar, T. Kartanas, M. M. Schneider, L. D. Cabrita, J. Christodoulou, T. P. J. Knowles

This study identifies the thermodynamic mechanisms underlying trigger factor binding to ribosomes and nascent chains during co-translational protein synthesis.

bioRxiv · Aug 23, 2023 · PreprintBiophysics

Single-molecule digital sizing of proteins in solution

G. Krainer, R. P. B. Jacquat, M. M. Schneider, T. J. Welsh, J. Fan, Q. A. E. Peter, E. A. Andrzejewska, G. Sneideriene, M. A. Czekalska, H. Ausserwoeger, L. Chai, W. E. Arter, K. L. Saar, T. W. Herling, T. M. Franzmann, , T. P. J. Knowles

This paper introduces smMDS, a method for digital sizing of proteins in solution, enabling sensitive and accurate measurement of protein sizes and interactions.

bioRxiv · Jul 12, 2023Biophysics

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

J. Nixon-Abell, F. S. Ruggeri, S. Qamar, T. W. Herling, M. A. Czekalska, Y. Shen, G. Wang, C. King, M. S. Fernandopulle, T. Sneideris, J. L. Watson, V. V. Pillai, W. Meadows, J. Henderson, J. E. Chambers, , P. St George Hyslop

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

bioRxiv · Mar 22, 2023Cell Biology

Non-specificity fingerprints for clinical stage antibodies in solution

T. W. Herling, G. I. Invernizzi, H. Ausserwoeger, J. R. Bjelke, T. Egebjerg, S. Lund, N. Lorenzen, T. P. J. Knowles

This study characterizes non-specific interactions of clinical-stage monoclonal antibodies using solution-based microfluidic technologies to generate quantitative non-specificity fingerprints.

bioRxiv · Feb 13, 2023 · PreprintBiophysics

Surface interaction patches link non-specific binding and phase separation of antibodies

H. Ausserwöger, G. Krainer, T. J. Welsh, T. Sneideris, M. M. Schneider, G. Invernizzi, T. W. Herling, N. Lorenzen, T. P. J. Knowles

This study links antibody non-specific binding to surface interaction patches and shows how they drive liquid-liquid phase separation under certain conditions.

bioRxiv · Mar 7, 2022 · PreprintBiophysics

The Hsc70 Disaggregation Machinery RemovesMonomer Units Directly from α-Synuclein FibrilEnds

M. M. Schneider, S. Gautam, T. W. Herling, E. Andrzejwska, G. Krainer, A. M. Miller, Q. A. E. Peter, F. S. Ruggeri, M. Vendruscolo, A. Bracher, C. M. Dobson, F.-U. Hartl, T. Knowles

This study shows the Hsc70-DnaJB1-Apg2 chaperone system removes monomer units directly from α-synuclein fibril ends, reversing aggregation without intermediate fragmentation.

bioRxiv · Nov 2, 2020Biophysics

Rapid Fractionation and Characterisation of Alpha-Synuclein Oligomers in Solution

W. E. Arter, C. K. Xu, M. Castellana-Cruz, T. W. Herling, G. Krainer, K. L. Saar, J. R. Kumita, C. M. Dobson, T. P. Knowles

This study demonstrates microfluidic free-flow electrophoresis for rapidly separating and characterizing alpha-synuclein oligomers in solution.

bioRxiv · Mar 10, 2020 · PreprintBiophysics