Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma
S. Bastola, M. S. Pavlyukov, Y. Ghochani, N. Sharma, M. A. Nakano, D. Muthukrishnan, S. Y. Yu, M. S. Kim, A. Sohrabi, N. P. Biscola, D. Yamashita, K. Anufrieva, R. Kawaguchi, Y. Qin, S. K. Seidlits, , H. Kornblum
This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.
bioRxiv · Oct 12, 2020 · PreprintCancer Biology