A. Y. Warren

Novel Methylation Markers in a Prostate Cancer Cohort are Associated with Disease Development and Relapse

The paper identifies novel methylation markers in a prostate cancer cohort associated with disease development and relapse, showing their predictive power for recurrence.

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

The paper traces the origin of four synchronous renal tumours in a child to an early embryonic MTOR mutation, showing its role in tumour development and clinical implications.

Autophagy maintains the homeostatic environment in the male reproductive accessory organs playing a key role in fertility

This study shows that autophagy is essential for maintaining the function of male reproductive accessory organs, and its inhibition leads to subfertility, with recovery upon autophagy restoration.

Clonal diversification and histogenesis of malignant germ cell tumours

This study analyzes the genome and transcriptome of 547 GCT histological units to explore clonal diversification and histogenesis, finding unifying genomic and transcriptional features across GCTs.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

3D-printed moulds for image-guided surgical biopsies: an open source computational platform

This paper develops an open-source computational platform to create 3D-printed moulds for image-guided surgical biopsies, achieving accurate co-registration of imaging and tissue samples.

Comprehensive characterisation of cell-free tumour DNA in plasma and urine of patients with renal tumours

The paper uses sequencing methods to show that cell-free tumour DNA levels are low in renal cancer but can still be informative with improved detection strategies.