N. Singh

This study identifies AtERF60 as a regulator of ABR1, showing that AtERF60 overexpression enhances basal resistance to PstDC3000 while its mutation increases susceptibility.

This study investigates co-aggregation and cross-seeding between prolactin and galanin in rat lactotrophs, revealing a novel mechanism of heterologous amyloid formation with implications for functional and pathological amyloids.

This study identifies proteostatic vulnerabilities in Her2+ breast cancers during resistance to Her2 inhibitors, showing that targeting ER quality control can overcome resistance.

This study identifies the mechanism by which derlin rhomboid pseudoproteases facilitate retrotranslocation of ER membrane substrates through substrate engagement and lipid thinning.

This study compares genomic features of early and late stage high grade serous ovarian carcinoma, finding no unique mutations or focal copy number alterations but noting differences in ploidy and copy number signatures.

The paper identifies nine promoter-variant strains of HIV-1C in Indian patients, showing genetic diversity in transcription factor binding sites that may affect viral latency and reservoir characteristics.

The paper shows that benzoxazinoid-mediated plant-soil feedbacks in cereals depend on soil type and genotype, with cultivar-specific effects on growth and insect resistance.

The paper develops and validates an HPLC-MS/MS method to rapidly quantify nine flavonoids and two phytohormones in Medicago truncatula leaf extracts.

This study shows that HCAR2/GPR109A maintains an immunoinhibitory retinal environment by regulating immune cell responses and preventing inflammation in retinal diseases.

This paper demonstrates that antimalarial drugs can block malaria transmission by targeting mosquitoes, remaining effective against resistant strains of both mosquitoes and parasites.

This study uses electron microscopy to analyze ultra-structural changes during encystation in Entamoeba invadens, identifying early nuclear modifications and structural transformations.

The paper sequences 242 Ae. tauschii accessions to study genetic diversity in the bread wheat D-subgenome, identifies disease resistance genes, and demonstrates their functional transfer into wheat.

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

This paper develops amyloid fibril-based hydrogels for 3D tumor spheroid modeling, showing enhanced drug resistance and cancer biomarker expression compared to 2D cultures.

This study shows clerodin induces mitotic abnormalities, G2/M arrest, and polyploidy in cells, similar to colchicine, through microtubule destabilization and shared binding site interaction.

This study identifies the GEMC1-MCIDAS transcriptional program as essential for multiciliogenesis in the choroid plexus and its role in preventing tumorigenesis.

This paper introduces heparin microislands to create chemotactic gradients for improved diabetic wound healing by enhancing cell migration and tissue regeneration.

The paper identifies regulatory RNA elements in bacterial 5' UTRs and ORFs using 3' end mapping, revealing new sRNA sponges and premature termination sites.

The paper identifies 54% of human PH domain-containing proteins as having PIP binding affinity, using single-molecule pulldown assays and a recursive-learning algorithm.

This study shows that wild-type p53 amyloid formation leads to cellular transformation and tumor formation in mice by enhancing survival, proliferation, and migration while suppressing tumor suppressors.

This study compares three nebulizers for protein delivery, showing that compressed air nebulizer delivers more precise small amounts of protein but compromises stability more than mesh nebulizer.

This study standardizes a root inoculation method to assess R. solanacearum pathogenicity in eggplant seedlings, showing it can distinguish virulence mutants from wild-type strains.

This study shows that additional blood feeding in Anopheles gambiae mosquitoes accelerates Plasmodium falciparum development, shortens the extrinsic incubation period, and increases malaria transmission potential.

This study screens nine tomato cultivars for resistance to R. solanacearum bacterial wilt in early seedlings under soil-free conditions, identifying Ayush as the most resistant and Ruby as the most susceptible.

This study shows ARHGEF3 promotes muscle regeneration and strength by enhancing autophagy, independent of mTORC2-Akt signaling, in both young and aged mice.

This study shows that alpha 6 integrins regulate cytokinesis by controlling RSK2 and MKLP1 expression in salivary gland epithelial cells.

This study evaluates the impact of Candida auris infection in neutropenic murine models, finding that neutrophil depletion leads to persistent fungal burden and unique behavioral changes.

This study identifies impaired death receptor signaling as a driver of resistance to CAR T cell therapy in B-cell leukemia by showing its role in tumor survival and T cell dysfunction.

This study examines the ontogeny and expression patterns of steroid hormone receptors in a mouse model of endometriosis, finding heterogeneous receptor expression that may impact therapeutic effectiveness.

This study shows that CD11c+ phagocytes in Peyer’s patches exhibit differential gene expression in response to Candida albicans, distinguishing between strains and contributing to mucosal barrier protection.