M. De Jesus

Topographical analysis of immune cell interactions reveals a biomechanical signature for immune cytolysis

The paper analyzes immune cell interactions using traction force microscopy to identify biomechanical features associated with cytotoxic T cell activity.

Apoptotic contraction drives target cell release by cytotoxic T cells

This study identifies apoptotic contraction as a mechanism driving CTL dissociation and target cell release.

Mechanically active integrins direct cytotoxic secretion at the immune synapse

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

Candida auris is rendered non-viable by medium-chain fatty acids

The study shows that octanoic and decanoic acids from coconut oil inhibit Candida auris growth, with decanoic acid being fungicidal, offering a potential natural antifungal strategy.

Impact of Candida auris infection in a neutropenic murine model

This study evaluates the impact of Candida auris infection in neutropenic murine models, finding that neutrophil depletion leads to persistent fungal burden and unique behavioral changes.

Assessment of Environmental and Occupational Exposure while Working with Candida auris a Multidrug Resistant (MDR) Fungus in the Animal Facility.

This study assesses environmental and occupational exposure to Candida auris during animal facility work using murine models and finds dose-dependent shedding and effective mitigation strategies.

Setting off the Alarms: Candida albicans Elicits Pro-Inflammatory Differential Gene Expression in Intestinal Peyer’s Patches

This study shows that CD11c+ phagocytes in Peyer’s patches exhibit differential gene expression in response to Candida albicans, distinguishing between strains and contributing to mucosal barrier protection.