Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids
Kaja Nicole Wächtershäuser, Jana V. Schneider, Alec Geßner, Geoffroy Andrieux, Ivan-Maximilano Kur, Nadine Duschek, Andreas Weigert, Melanie Boerries, Michael A. Rieger, Ernst H. K. Stelzer, Francesco Pampaloni, Sjoerd J. L. van Wijk
This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.
Signal Transduction and Targeted Therapy · Jun 1, 2026Peer-reviewedCancer Biology