Francesco Pampaloni

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

Evolvoid: A genetic algorithm for shaping optimal cellular constructs

Evolvoid uses genetic algorithms to optimize cellular construct morphology by balancing cell viability and surface energy through a fitness function based on biophysical laws.

BRAT1 - a new therapeutic target for glioblastoma

This study identifies BRAT1 as a key driver of glioblastoma growth and invasion, showing that its inhibition with CurD reduces tumor migration and enhances radiation sensitivity.

A hybrid bioprinting-electrospinning platform integrating nanofibers and mesenchymal cell spheroids for customizable wound healing dressings

This paper introduces a hybrid bioprinting-electrospinning platform for customizable wound healing dressings using nanofibers and mesenchymal cell spheroids, showing improved cell viability and wound closure.

Open-hardware solutions for light sheet microscopy specimen chambers

This paper introduces open-hardware solutions for light sheet microscopy specimen chambers using 3D printing, silicone injection moulding, and FEP-foil thermoforming to improve flexibility, sealing, and contamination prevention.

HCS-3DX, a next-generation AI-driven automated 3D-oid high-content screening system

HCS-3DX is a new AI-driven system for 3D-oid high-content screening that improves resolution and single-cell analysis in 3D tumor models.

3D-Cell-Annotator: an open-source active surface tool for single cell segmentation in 3D microscopy images

3D-Cell-Annotator provides a tool for automated 3D cell segmentation in microscopy images using active surfaces and shape descriptors, achieving expert-level precision.