Andreas Weigert

IL-38 limits alloreactivity through modulating myeloid and T cell activation

This study shows IL-38 reduces monocyte antigen presentation and promotes regulatory T-cell expansion, thereby limiting alloreactivity in GvHD models.

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

Immunomodulatory endothelial cells contribute to T cell recruitment and activation through antigen presentation on MHC class II

This paper identifies immunomodulatory endothelial cells (IMEC) that present antigens on MHC class II and activate T cells in atherosclerosis.

Ferroptosis governs lymphatic vessel growth and regression

This study identifies ferroptosis as a regulator of lymphatic vessel growth and regression, showing its role in development and injury response through metabolic and lipid pathway mechanisms.