Author

Natasha Sieczkiewicz

University of Rochester

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Andrei SeluanoviD· 2 shared Cheyenne RechsteineriD· 2 shared Eric C. Hillpot· 2 shared Francesco MorandiniiD· 2 shared John C. MartineziD· 2 shared Matthew A. SimoniD· 2 shared Seyed Ali BiashadiD· 2 shared Vera A. GorbunovaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Andrei SeluanovORCID

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2 papers

Recent·Most cited

cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation

John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner, Lucinda Fitzgibbons, Natasha Sieczkiewicz, Xiaoyan Liao, Weijie He, Sung Jae Bae, Michael E. Meadow, Eric C. Hillpot, Joseph Cutting, Victoria Paige, Max Zacher, Seyed Ali Biashad, Matthew A. Simon, , Vera A. Gorbunova

This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.

Nature Aging · Aug 25, 2026Peer-reviewedCell Biology

SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice

Seyed Ali Biashad, Eric C. Hillpot, Francesco Morandini, Cheyenne Rechsteiner, Victoria Paige, Gregory Tombline, Minseon Lee, Zhizhong Zheng, Yuan Liang, John C. Martinez, Natasha Sieczkiewicz, Zhihui Zhang, Valentin Pavlovich Volobaev, Denis Firsanov, Matthew A. Simon, , Vera A. Gorbunova

This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.

bioRxiv · Mar 24, 2025 · PreprintMolecular Biology