SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice
Seyed Ali Biashad, Eric C. Hillpot, Francesco Morandini, Cheyenne Rechsteiner, Victoria Paige, Gregory Tombline, Minseon Lee, Zhizhong Zheng, Yuan Liang, John C. Martinez, Natasha Sieczkiewicz, Zhihui Zhang, Valentin Pavlovich Volobaev, Denis Firsanov, Matthew A. Simon, , Vera A. Gorbunova
This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.
bioRxiv · Mar 24, 2025 · PreprintMolecular Biology