IL4i1-sourced oncometabolites promote neuroblastoma cell survival
Camille Guyot, Lee-Ann Van de Velde, Lisa Kainacher, Johanna Ruoff, Ana Bici, Nicolas Bernard Peterson, Emma Kaitlynn Allen, Barbara A. Steigenberger, Assa Yeroslaviz, Jun Yang, Leonie Zeitler, Paul Glyndwr Thomas, Peter J. Murray
This study shows that IL4i1 metabolites from immune cells suppress ferroptosis in neuroblastoma cells by scavenging free radicals and activating NRF2, promoting tumor survival.
bioRxiv · Aug 7, 2025 · PreprintCancer Biology