Author

Nicolas Poulain

Cancer Research UK Scotland Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

John P. C. Le QuesneiD· 3 shared Fiona BallantyneiD· 2 shared Ian R. PowleyiD· 2 shared Leah Officer-JonesiD· 2 shared Marco SerenoiD· 2 shared Adalberto Claudio QuirosiD· 1 shared Ana TeodòsioiD· 1 shared Antonis E. KoromilasiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

John P. C. Le QuesneORCID

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Author profile →

3 papers

Recent·Most cited

Spatial resolution of transcriptomic plasticity states underpinning lethal morphologies in lung adenocarcinoma

Hannah L. Williams, Nicolas Poulain, Ian R. Powley, Silvia Martinelli, Robert Bielik, Holly Leslie, Colin Nixon, Claire R. Wilson, Marco Sereno, Zhangyi He, Leah Officer-Jones, Fiona Ballantyne, Rachel L. Pennie, Colin S. Wood, D. J. Lewis, , John P. C. Le Quesne

This study uses spatial transcriptomics to analyze gene expression in lung adenocarcinoma morphologies, revealing plasticity and gene expression trajectories linked to lethal growth patterns.

Modern Pathology · Jan 9, 2026Peer-reviewedCancer Biology

A histomorphological atlas of resected mesothelioma discovered by self-supervised learning from 3446 whole-slide images

Farzaneh Seyedshahi, Kai Rakovic, Nicolas Poulain, Adalberto Claudio Quiros, Ian R. Powley, Cathy J. Richards, Hussein Uraiby, Sonja Klebe, David Allan Moore, Apostolos Nakas, Claire Wilson, Marco Sereno, Leah Officer-Jones, Catherine Ficken, Ana Teodòsio, , John P. C. Le Quesne

This paper uses self-supervised learning on 3446 H&E-stained mesothelioma slides to create a histomorphological atlas, achieving high predictive performance and revealing molecular insights.

Nature Communications · Oct 7, 2025Peer-reviewedPathology

Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason Earl Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John P. C. Le Quesne, Tuomas Tammela, Antonis E. Koromilas

This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology