Author

Nour Ghaddar

Jewish General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Antonis E. KoromilasiD· 2 shared Hyungdong KimiD· 2 shared Jia Yi ZouiD· 2 shared Maria HatzoglouiD· 2 shared Nahum SonenbergiD· 2 shared Peter WalteriD· 2 shared Shiqi DiaoiD· 2 shared Atsuo T. SasakiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Antonis E. KoromilasORCID

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2 papers

Recent·Most cited

eIF2B Selectively Anchors and Activates Mutant KRAS

Hyungdong Kim, Shiqi Diao, Kwang‐Jin Cho, Hyun-Ro Lee, Junchen Liu, Pascal F. Egea, Tatu Pantsar, Milla Kurki, Nour Ghaddar, Shuo Wang, Jia Yi Zou, Mehdi Amiri, Ritchel B. Gannaban, John F. Hancock, Kylie M. Rice, , Antonis E. Koromilas

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

bioRxiv · Nov 10, 2025 · PreprintCancer Biology

Lineage plasticity of the integrated stress response is a hallmark of cancer evolution.

Shiqi Diao, Jia Yi Zou, Shuo Wang, Nour Ghaddar, Jason Earl Chan, Hyungdong Kim, Nicolas Poulain, Constantinos Koumenis, Maria Hatzoglou, Peter Walter, Nahum Sonenberg, John P. C. Le Quesne, Tuomas Tammela, Antonis E. Koromilas

This study shows that activation of the integrated stress response (ISR) drives tumor evolution and therapy resistance by promoting dedifferentiation and stemness in lung adenocarcinoma.

bioRxiv · Feb 10, 2025 · PreprintCancer Biology