Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.
Sofia Kakava, Mary Gonzalez Melo, Wai Hang Cheng, Ilaria Del Gaudio, David Viertl, S. Bernhard, Eveline Schlumpf, Mikaël Croyal, Evelina Volovičeva, Jianjia Fan, Carlos Barrón, Antonis Katsoulas, Vasileia Kalaitzaki, Nora Jüdt, Thorsten Buch, , Jérôme Robert
The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.
bioRxiv · May 23, 2025 · PreprintNeuroscience