Jianjia Fan

Repeated mild traumatic brain injury does not affect sleep or epileptiform activity one-month post-injury in a knock-in mouse model of Alzheimer's disease

This study investigates the effects of repeated mild traumatic brain injury on sleep, epileptiform activity, and Alzheimer's disease pathology in a knock-in mouse model one month post-injury.

Repetitive mild traumatic brain injury causes neuronal damage in the APP/PS1 mouse model of Alzheimer's disease without an enduring impact on amyloid pathology, sleep, or epileptiform activity

Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain.

The paper investigates how high-density lipoproteins (HDL) cross the blood-brain barrier, showing that LDLR and apoE composition determine HDL entry and brain localization.

Leveraging the power of 3D brain-wide imaging and mapping tools for brain injury research in murine models

The paper describes a whole-brain imaging pipeline to study neuronal activity changes after traumatic brain injury in mice, finding reduced c-Fos cell density in injured brains.

Altered tau in rTg4510 mice after a single interfaced CHIMERA traumatic brain injury

This study examines the effects of a single moderate-severe TBI in rTg4510 mice using CHIMERA, finding divergent tauopathy and autophagolysosome responses in surviving mice.