Author

Norbert Brieske

Max Planck Institute for Molecular Genetics

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Lars WittleriD· 2 shared Adriano BolondiiD· 1 shared Andrea EspositoiD· 1 shared Andrea M. ChiarielloiD· 1 shared Bernd Timmermann· 1 shared Carlo AnnunziatellaiD· 1 shared Chiara AnaniaiD· 1 shared Christina PaliouiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersDevelopmental Biology

Lars WittlerORCID

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2 papers

Recent·Most cited

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

Chiara Anania, Rafael D. Acemel, Johanna Jedamzick, Adriano Bolondi, Giulia Cova, Norbert Brieske, Ralf Kühn, Lars Wittler, Francisca Martinez Real, Darío G. Lupiáñez

The paper investigates how clustered-CTCF boundaries function in vivo, showing that individual CTCF sites can override other factors and that insulation strength modulates gene expression and phenotypes.

Nature Genetics · Jul 1, 2022Peer-reviewedDevelopmental Biology

Preformed Chromatin Topology Assists TranscriptionalRobustness of Shh during Limb Development

Christina Paliou, Philine Guckelberger, Robert Schöpflin, Verena Heinrich, Andrea Esposito, Andrea M. Chiariello, Simona Bianco, Carlo Annunziatella, Johannes Helmuth, Stefan A. Haas, Ivana Jerković, Norbert Brieske, Lars Wittler, Bernd Timmermann, Mario Nicodemi, , Guillaume Andrey

The paper shows that preformed chromatin topology supports robust Shh transcription during limb development, with CTCF and ZRS alleles influencing enhancer-promoter communication.

Proceedings of the National Academy of Sciences · May 30, 2019Peer-reviewedDevelopmental Biology