O. Daumke

Identification of drug-like molecules targeting the ATPase activity of dynamin-like EHD4

The paper identifies a drug-like molecule that inhibits EHD4's liposome-stimulated ATPase activity and provides SAR insights for improved inhibitor design.

Structure-based humanization of a therapeutic antibody for Multiple Myeloma

The paper describes a method to humanize a therapeutic antibody for Multiple Myeloma using structural information to optimize binding affinity while minimizing antigenicity.

Elucidating the activation mechanism for GBP1 oligomerization

This study reveals the activation mechanism of GBP1 oligomerization through cryo-EM structures, showing nucleotide-dependent conformational changes drive dimerization, oligomerization, and membrane binding for pathogen encapsulation.

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

This study identifies a mutation in IRF4 that alters DNA-binding specificity and gene regulation in lymphoma, leading to disease-specific gene up-regulation.

Structural insights into crista junction formation by the Mic60-Mic19 complex

This study reveals the structural role of the Mic60-Mic19 complex in forming mitochondrial crista junctions by acting as a molecular strut that controls their architecture.

Cryo-electron tomography reveals structural insights into the membrane binding and remodeling activity of dynamin-like EHDs

The paper uses cryo-electron tomography to determine the structure of EHD4 filaments on a membrane, revealing insights into their remodeling activity.

Disrupting the CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation

This study shows that disrupting the CD177:PR3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation in ANCA-associated vasculitis.

Quantification and demonstration of the collective constriction-by-ratchet mechanism in the dynamin molecular motor

This study demonstrates the collective constriction-by-ratchet mechanism of dynamin using single-molecule FRET and simulations.

Polymer-like model to study the dynamics of dynamin filaments on deformable membrane tubes

The paper develops a polymer-like model to study dynamin filament dynamics on deformable membrane tubes, finding that filament pitch, not radius, is sensitive to membrane tension and stiffness.

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.