This study investigates how tick-borne encephalitis virus capsid protein binds membranes and recruits RNA, showing electrostatic interactions and membrane insertion.

bioRxiv · Oct 6, 2022Biochemistry

Dynamin2 stabilizes plasma membrane-connected caveolae by restraining fission

E. Larsson, B. Moren, K.-A. McMahon, R. G. Parton, R. Lundmark

This study uses live-cell microscopy to show that Dyn2 stabilizes caveolae by preventing their fission, independent of its GTPase activity or EHD2.

bioRxiv · May 25, 2022Cell Biology

Membrane insertion mechanism of the caveolae coat protein Cavin1

K.-c. Liu, H. Pace, E. Larsson, S. Hossain, A. Kabedev, A. Shukla, V. Jerschabek, J. Mohan, C. A. S. Bergstrom, M. Bally, C. Schwieger, M. Hubert, R. Lundmark

This study reveals how Cavin1 inserts into membranes through PI(4,5)P2-dependent adsorption and helix insertion, facilitated by flanking regions and co-assembly with Caveolin1.

bioRxiv · Mar 23, 2021Biochemistry

Lipid accumulation promotes scission of caveolae

M. Hubert, E. Larsson, N. V. G. Vegesna, M. Ahnlund, A. I. Johansson, L. W. K. Moodie, R. Lundmark

The paper shows that cholesterol and glycosphingolipids accumulate in caveolae, reducing their neck diameter and promoting scission from the cell surface, counteracted by EHD2.

bioRxiv · Jan 22, 2020Biochemistry

EHD2-mediated restriction of caveolar dynamics regulates cellular lipid uptake

C. Matthaeus, I. Lahmann, S. Kunz, W. Jonas, A. A. Melo, M. Lehmann, E. Larsson, R. Lundmark, M. Kern, M. Blueher, V. Hauke, D. N. Mueller, A. Schuermann, C. Birchmeier, O. Daumke

This study shows that EHD2 restricts caveolar dynamics to regulate lipid uptake, with loss of EHD2 leading to increased fat accumulation and obesity in mice.

bioRxiv · Mar 7, 2019Cell Biology