W. Kang

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Kilohertz volumetric imaging of in-vivo dynamics using squeezed light field microscopy

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

Reproducing Left Ventricular Twist by Mimicking Myocardial Fiber Orientation Using 3D Bioprinting-assisted Tissue Assembly

This paper develops a 3D bioprinting-assisted method to create a chamber-like structure with myocardial fiber orientation, demonstrating left ventricular twist and structural-functional synchrony.

ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity

The paper identifies a stem-like proliferative state in prostate epithelial cells driven by ERG activation, which transitions to luminal cells and is associated with specific chromatin states.

Spin-coupled electron densities of iron-sulfur cluster imaged by in situ serial Laue diffraction

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

MADET: A Manually Curated Knowledgebase for Microbiomic Effects on Efficacy and Toxicity of Anticancer Treatments

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

Metagenomic and Metabolomic Analyses Reveal Synergistic Effects of Fecal Microbiota Transplantation and Anti-PD-1 Therapy on Treating Colorectal Cancer

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

Stiffness Regulates Intestinal Stem Cell Fate

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

Tumor invasion as non-equilibrium phase separation

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA

The paper uses single-molecule fluorescence to show that RNA release precedes RNA polymerase dissociation during bacterial intrinsic termination, revealing a recycling stage where RNAP diffuses and can reinitiate transcription.