Author

L. V. Danai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:metabolism & bioenergetics· 4 Assay:metabolomics· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. N. Lau· 3 shared M. G. Vander Heiden· 3 shared A. M. Darnell· 2 shared A. M. Westermark· 2 shared A. Muir· 2 shared C. A. Lewis· 2 shared D. Y. Gui· 2 shared E. C. Lien· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

A. N. Lau

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Effects of aging on glucose and lipid metabolism in mice

E. C. Lien, N. Vu, A. M. Westermark, L. V. Danai, A. N. Lau, Y. Gultekin, M. A. Kukurugya, B. D. Bennett, M. Vander Heiden

This study examines how aging affects glucose and lipid metabolism in mice, finding that NAD+ levels remain stable but lipid metabolism increases in aged tissues.

bioRxiv · Dec 17, 2023Physiology

Cancer tissue of origin constrains the growth and metabolism of metastases

S. Sivanand, Y. Gultekin, P. Winter, S. Y. Vermeulen, K. Tchourine, K. L. Abbott, L. V. Danai, F. Gourgue, B. T. Do, K. Crowder, T. Kunchok, A. N. Lau, A. M. Darnell, A. Jefferson, S. Morita, , M. G. Vander Heiden

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

bioRxiv · Aug 17, 2022Cancer Biology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Quantification of microenvironmental metabolites in murine cancer models reveals determinants of tumor nutrient availability

M. R. Sullivan, L. V. Danai, C. A. Lewis, S. H. Chan, D. Y. Gui, T. Kunchok, E. A. Dennstedt, M. G. Vander Heiden, A. Muir

The paper quantifies microenvironmental metabolites in murine cancer models and identifies factors affecting tumor nutrient availability.

bioRxiv · Jan 3, 2019Cancer Biology

Environmental cystine drives glutamine anaplerosis and sensitizes cells to glutaminase inhibition

A. Muir, L. V. Danai, D. Y. Gui, C. Y. Waingarten, M. G. Vander Heiden

The paper shows that environmental cystine levels influence glutamine anaplerosis and glutaminase dependence in cancer cells.

bioRxiv · Apr 11, 2017Biochemistry