Y. Ivarsson

Proteome-scale characterisation of motif-based interactome rewiring by disease mutations

The paper characterizes how disease mutations in intrinsically disordered regions modulate protein interactions mediated by short linear motifs, identifying both loss and gain of interactions.

Evaluation of affinity-purification coupled to mass spectrometry approaches for capture of short linear motif-based interactions

The paper evaluates biotinylated peptide pulldown and PRISMA coupled to mass spectrometry for capturing SLiM-based interactions, finding biotin-peptide pulldown more effective for validation.

A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and a panel of RNA viruses

A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and multiple RNA viruses by preventing their uptake through receptor-mediated endocytosis.

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs

The paper uses phage-based screening to identify 1,712 virus-host interactions mimicking host short linear motifs, revealing therapeutic targets for broad-spectrum antivirals.

Large-scale identification of phospho-modulated motif-based protein-protein interactions

The paper identifies 252 phospho-modulated short linear motif-based protein-protein interactions using a proteomic peptide-phage display library and validates several through affinity measurements and structural analysis.

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

The paper identifies coronavirus-host protein interaction motifs, revealing SARS-CoV-2 specific mechanisms and a peptide-based inhibitor that blocks infection.

Proteome-scale amino-acid resolution footprinting of protein-binding sites in the intrinsically disordered regions of the human proteome

The paper introduces HD2, a proteome-scale method for identifying and characterizing SLiM-mediated protein interactions with amino acid resolution, and provides tools for analyzing the results.

Short linear motif based interactions and dynamics of the ezrin, radixin, moesin and merlin FERM domains

The paper identifies and characterizes short linear motifs binding to FERM domains of ERM proteins and merlin, revealing allosteric regulation between ligands.

Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to endocytosis and autophagy

Affinity measurements confirmed binding of short linear motifs in the cytoplasmic tails of ACE2 and integrin β3, linking these receptors to endocytosis and autophagy.

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

The paper identifies calcineurin (CN) substrates and interactors using a combination of experimental and computational methods, revealing novel roles for CN in regulating nuclear pore complex proteins.