Author

O. SOUTOURINA

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:C. elegans· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. Dupuy· 3 shared J. PELTIER· 3 shared A. Hamiot· 2 shared A. Maikova· 2 shared J. R. Garneau· 2 shared L.-C. Fortier· 2 shared P. Boudry· 2 shared A. A. Umansky· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

B. Dupuy

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Identification of an anti-CRISPR protein that inhibits the CRISPR-Cas type I-B system in Clostridioides difficile

P. Muzyukina, A. Shkaruta, N. M. Guzman, J. Andreani, A. L. Borges, J. Bondy-Denomy, A. Maikova, E. Semenova, K. Severinov, O. SOUTOURINA

This study identifies AcrIB2, an anti-CRISPR protein from a C. difficile phage that inhibits the type I-B CRISPR-Cas system, showing that a partial cas operon is sufficient for interference.

bioRxiv · May 22, 2023 · PreprintMicrobiology

The Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor

A. L. M. Royer, A. A. Umansky, M.-M. Allen, J. R. Garneau, M. O. Bedoya, J. A. Kirk, G. Govoni, R. P. Fagan, O. Soutourina, L.-C. Fortier

This paper demonstrates that SlpA is a common receptor for multiple C. difficile phages, enabling the rational design of phage cocktails.

bioRxiv · Sep 19, 2022Microbiology

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

M. Oberkampf, A. Hamiot, P. Altamirano-Silva, P. Belles-sancho, Y. D. Tremblay, N. DiBenedetto, R. Seifert, O. SOUTOURINA, L. Bry, B. Dupuy, J. PELTIER

This study identifies c-di-AMP as a key signaling molecule in Clostridioides difficile that regulates osmolyte uptake and bile salt resistance, essential for gut colonization.

bioRxiv · Aug 23, 2021 · PreprintMicrobiology

Identification of RNAs bound by Hfq reveals widespread RNA partners and a sporulation regulator in the human pathogen Clostridioides difficile

P. Boudry, E. Piattelli, E. Drouineau, J. Peltier, A. Boutserin, M. Lejars, E. Hajnsdorf, M. Monot, B. Dupuy, I. Martin-Verstraete, D. Gautheret, C. Toffano-Nioche, O. SOUTOURINA

The paper identifies RNAs bound by Hfq in C. difficile, revealing new RNA partners and a role for one ncRNA in sporulation regulation.

bioRxiv · Nov 25, 2020Microbiology

Type I toxin-antitoxin systems contribute to mobile genetic elements maintenance in Clostridioides difficile and can be used as a counter-selectable marker for chromosomal manipulation

J. Peltier, A. Hamiot, J. R. Garneau, P. Boudry, A. Maikova, L.-C. Fortier, B. Dupuy, O. Soutourina

The paper characterizes type I toxin-antitoxin systems in C. difficile prophages, showing their role in prophage stability and introducing them as counter-selectable markers for chromosomal manipulation.

bioRxiv · Mar 4, 2020Microbiology