Author

N. DiBenedetto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:metabolism & bioenergetics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. Bry· 3 shared B. Dupuy· 2 shared J. PELTIER· 2 shared R. Lavin· 2 shared V. Yeliseyev· 2 shared A. B. Onderdonk· 1 shared A. Hamiot· 1 shared A. L. Sonenshein· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

L. Bry

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5 papers

Recent·Most cited

Unique growth and morphology properties of Clade 5 Clostridioides difficile strains revealed by single-cell time-lapse microscopy

J. W. Ribis, C. A. Nieto-Acuna, N. DiBenedetto, A. Mehra, Q. Dong, I. L. Nagawa, I. El Meouche, B. B. Aldridge, M. J. Dunlop, R. Tamayo, A. Singh, A. Shen

This study identifies distinct growth and chaining properties in Clade 5 Clostridioides difficile strains using time-lapse microscopy, linked to the cmr switch sequence orientation.

PLOS Pathogens · May 21, 2025Peer-reviewedMicrobiology

Clostridium scindens colonization of gnotobiotic mice promotes a chronic unresolving infection with Clostridioides difficile

M. Graham, N. DiBenedetto, M. Delaney, R. Lavin, A. Pavao, V. Yeliseyev, L. Bry

This study shows that C. scindens colonization in gnotobiotic mice reduces acute C. difficile infection severity but does not prevent chronic infection development.

bioRxiv · Jun 12, 2022 · PreprintMicrobiology

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

M. Oberkampf, A. Hamiot, P. Altamirano-Silva, P. Belles-sancho, Y. D. Tremblay, N. DiBenedetto, R. Seifert, O. SOUTOURINA, L. Bry, B. Dupuy, J. PELTIER

This study identifies c-di-AMP as a key signaling molecule in Clostridioides difficile that regulates osmolyte uptake and bile salt resistance, essential for gut colonization.

bioRxiv · Aug 23, 2021 · PreprintMicrobiology

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model

C. C. Neto, B. M. Mortzfeld, J. R. Turbitt, S. K. Bhattarai, V. Yeliseyev, N. DiBenedetto, L. M. Bry, V. Bucci

This study shows that a proanthocyanidin-enriched cranberry extract alters bacterial community dynamics in a gnotobiotic mouse model, with transient increases in mucin-degrading and anti-inflammatory bacteria.

bioRxiv · Feb 25, 2021Microbiology

The mechanisms of in vivo commensal control of Clostridioides difficile virulence

B. P. Girinathan, N. DiBenedetto, J. N. Worley, J. Peltier, M. Arrieta-Ortiz, S. R. C. Immanuel, R. Lavin, M. L. Delaney, C. Cummins, A. B. Onderdonk, G. K. Gerber, A. L. Sonenshein, N. Baliga, B. Dupuy, L. Bry

This study identifies how commensal bacteria influence Clostridioides difficile virulence through metabolic and regulatory mechanisms in a mouse model.

bioRxiv · Jan 4, 2020Microbiology