Author

L.-C. Fortier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:C. elegans· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

J. R. Garneau· 4 shared M.-M. Allen· 2 shared O. Soutourina· 2 shared R. P. Fagan· 2 shared A. A. Umansky· 1 shared A. Hamiot· 1 shared A. L. M. Royer· 1 shared A. Maikova· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersMicrobiology

J. R. Garneau

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5 papers

Recent·Most cited

Molecular mechanism of bacteriophage tail contraction- structure of an S-layer-penetrating bacteriophage

J. S. Wilson, L.-C. Fortier, R. P. Fagan, P. A. Bullough

This study reveals the atomic structures of a bacteriophage with a contractile tail that infects Clostridioides difficile, showing that tail contraction alone provides enough energy to penetrate the S-layer and cell wall without enzymatic activity.

bioRxiv · Aug 4, 2023Microbiology

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

Q. Dong, H. Lin, M.-M. Allen, J. R. Garneau, J. K. Sia, R. C. Smith, F. Haro, T. McMillen, R. L. Pope, C. Metcalfe, V. Burgo, C. Woodson, N. Dylla, C. Kohout, A. Sundararajan, , E. G. Pamer

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

bioRxiv · Jan 12, 2023Microbiology

The Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor

A. L. M. Royer, A. A. Umansky, M.-M. Allen, J. R. Garneau, M. O. Bedoya, J. A. Kirk, G. Govoni, R. P. Fagan, O. Soutourina, L.-C. Fortier

This paper demonstrates that SlpA is a common receptor for multiple C. difficile phages, enabling the rational design of phage cocktails.

bioRxiv · Sep 19, 2022Microbiology

Type I toxin-antitoxin systems contribute to mobile genetic elements maintenance in Clostridioides difficile and can be used as a counter-selectable marker for chromosomal manipulation

J. Peltier, A. Hamiot, J. R. Garneau, P. Boudry, A. Maikova, L.-C. Fortier, B. Dupuy, O. Soutourina

The paper characterizes type I toxin-antitoxin systems in C. difficile prophages, showing their role in prophage stability and introducing them as counter-selectable markers for chromosomal manipulation.

bioRxiv · Mar 4, 2020Microbiology

PhageTerm: a Fast and User-friendly Software to Determine Bacteriophage Termini and Packaging Mode using randomly fragmented NGS data

J. R. Garneau, F. Depardieu, L.-C. Fortier, D. Bikard, M. Monot

PhageTerm determines bacteriophage DNA termini and packaging modes using NGS data, validated on known phages and new isolates.

bioRxiv · Feb 16, 2017Microbiology