Author

P. D. Allen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Fischer· 1 shared A. L. Chaly· 1 shared A. R. Horswill· 1 shared A. Uryas· 1 shared B. Lin· 1 shared C. Diggle· 1 shared C. P. Parker· 1 shared C. R. Shanrock· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperMicrobiology

A. J. Fischer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

T. T. Joseph, W. Bu, O. Haji-Ghassemi, Y. S. Chen, K. Woll, P. D. Allen, G. Brannigan, F. van Petegem, R. G. Eckenhoff

This study shows propofol directly binds and inhibits RyR1, reducing Ca2+ release and potentially protecting against malignant hyperthermia.

bioRxiv · Jan 10, 2024 · PreprintPharmacology & Toxicology

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

T. Yamazawa, T. Kobayashi, N. Kurebayashi, M. Konishi, S. Noguchi, T. Inoue, Y. U. Inoue, I. Nishino, S. Mori, H. Iinuma, N. Manaka, H. Kagechika, A. Uryas, J. Adams, J. R. Lopez, , T. Murayama

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

bioRxiv · Jul 2, 2020 · PreprintPharmacology & Toxicology

MgrA regulates interaction of Staphylococcus aureus with mucin

C. P. Parker, N. Akil, C. R. Shanrock, P. D. Allen, A. L. Chaly, H. Crosby, J. Kwiecinski, A. R. Horswill, A. J. Fischer

The paper measures S. aureus binding to mucin and identifies MgrA and Ebh/SraP as regulators of this interaction.

bioRxiv · Apr 9, 2020 · PreprintMicrobiology