Author

Y. S. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

F. Van Petegem· 2 shared A. Rohaim· 1 shared B. J. Moeller· 1 shared B. J. Murphy· 1 shared B. M. Zid· 1 shared B. Roux· 1 shared D. Lorks· 1 shared D. Riedel· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

F. Van Petegem

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Author profile →

4 papers

Recent·Most cited

Localising elements in single-particle reconstructions by REEL-EM: Reconstructed Electron Energy-Loss - Elemental Mapping

O. Pfeil-Gardiner, H. V. D. Rosa, D. Riedel, Y. S. Chen, D. Lorks, P. Kukelhan, M. Linck, H. Muller, F. Van Petegem, B. J. Murphy

This paper introduces REEL-EM, a method combining EELS and single-particle image processing to enable elemental mapping in cryo-preserved macromolecular complexes, demonstrating reliable localization of abundant elements.

bioRxiv · Jan 18, 2024Biophysics

Propofol directly binds and inhibits skeletal muscle ryanodine receptor 1 (RyR1)

T. T. Joseph, W. Bu, O. Haji-Ghassemi, Y. S. Chen, K. Woll, P. D. Allen, G. Brannigan, F. van Petegem, R. G. Eckenhoff

This study shows propofol directly binds and inhibits RyR1, reducing Ca2+ release and potentially protecting against malignant hyperthermia.

bioRxiv · Jan 10, 2024 · PreprintPharmacology & Toxicology

Crystal structure of a bacterial CNNM magnesium transporter

Y. S. Chen, G. Kozlov, J. Armitano, B. J. Moeller, R. Fakih, A. Rohaim, B. Roux, J. E. Burke, K. Gehring

The paper determines the crystal structure of an archaeal CNNM protein bound to Mg2+-ATP, revealing its transmembrane fold and suggesting it functions as a cation transporter.

bioRxiv · Feb 11, 2021Biophysics

Mitochondrial volume fraction and translation speed impact mRNA localization and production of nuclear-encoded mitochondrial proteins

T. Tsuboi, M. P. Viana, F. Xu, J. Yu, R. Chanchani, X. G. Arceo, E. Tutucci, J. Choi, Y. S. Chen, R. H. Singer, S. M. Rafelski, B. M. Zid

bioRxiv · Oct 10, 2019Cell Biology