M. Blasi

Distinct upper airway epithelium interferon-stimulated and profibrotic gene expression between adult and infant rhesus macaques infected with SARS-CoV-2

This study compares SARS-CoV-2 infection effects in adult and infant rhesus macaques, finding distinct interferon-stimulated and profibrotic gene expression patterns in upper airway epithelium.

BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes

This study shows SARS-CoV-2 can infect kidney podocytes via ACE2 and BSG/CD147 receptors, causing cell death and foot process retraction, and suggests a stem cell model for drug screening.

Persistent Immunogenicity of Integrase Defective Lentiviral Vectors delivering membrane tethered Native-Like HIV-1 Envelope Trimers

This study shows that IDLV vectors with membrane-tethered native-like HIV-1 Env trimers induce faster and longer-lasting anti-Env IgG responses in mice and macaques, with some animals developing neutralization activity against HIV-1.

Protective transfer: Maternal passive immunization with a rotavirus-neutralizing dimeric IgA protects against rotavirus disease in suckling neonates

Oral Hsp90 inhibitor, SNX-5422, attenuates SARS-CoV-2 replication and dampens inflammation in airway cells.

This study shows that the Hsp90 inhibitor SNX-5422 reduces SARS-CoV-2 replication and inflammation in airway cells, suggesting its potential as an early therapeutic.

Proliferation of HIV-infected renal epithelial cells following virus acquisition from infected macrophages

This study shows HIV-1 infected macrophages transfer virus to renal epithelial cells, leading to proliferation and potential persistence of infection in the kidney.

Immunogenicity, safety and efficacy of sequential immunizations with an SIV-based IDLV expressing CH505 Envs

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.