Author

P. J. Bredenbeek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. J. Snijder· 3 shared D. Ninaber· 2 shared M. J. van Hemert· 2 shared M. Kikkert· 2 shared M. Thaler· 2 shared P. Hiemstra· 2 shared Y. Wang· 2 shared A. M. van der Does· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

E. J. Snijder

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A third vaccination with a single T cell epitope protects against SARS-CoV-2 infection in the absence of neutralizing antibodies

I. N. Pardieck, E. T. I. van der Gracht, D. M. B. Veerkamp, F. M. Behr, S. van Duikeren, G. Beyrend, J. Rip, R. Nadafi, T. C. van der Sluis, E. Beyranvand Nejad, N. Mulling, D. J. Brasem, M. G. M. Camps, S. K. Myeni, P. J. Bredenbeek, , R. Arens

A third dose of a single T cell epitope vaccine protects mice from SARS-CoV-2 infection without neutralizing antibodies by enhancing effector-memory and tissue-resident memory T cells.

bioRxiv · Dec 15, 2021 · PreprintImmunology

Impact of human airway epithelial cellular composition on SARS-CoV-2 infection biology

Y. Wang, M. Thaler, D. Ninaber, A. M. van der Does, N. S. S. Ogando, H. Beckert, C. Taube, C. Salgado Benvindo Da Silva, E. J. Snijder, P. J. Bredenbeek, P. Hiemstra, M. J. van Hemert

This study examines how the composition of human airway epithelial cells affects SARS-CoV-2 infection, finding that prolonged culture time and higher proportions of ciliated and goblet cells increase viral load.

bioRxiv · Jul 21, 2021 · PreprintCell Biology

Suramin inhibits SARS-CoV-2 infection in cell culture by interfering with early steps of the replication cycle

C. Salgado-Benvindo, M. Thaler, A. Tas, N. S. Ogando, P. J. Bredenbeek, D. Ninaber, Y. Wang, P. Hiemstra, E. J. Snijder, M. J. van Hemert

This study shows suramin inhibits SARS-CoV-2 replication in cell cultures by targeting early replication steps, with potential for clinical evaluation.

bioRxiv · May 6, 2020Microbiology

The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model

R. Knaap, R. Fernandez-Delgado, T. J. Dalebout, N. Oreshkova, P. J. Bredenbeek, L. Enjuanes, I. Sola, E. J. Snijder, M. Kikkert

This study shows that disrupting the deubiquitinating activity of MERS-CoV PLpro enhances innate immune responses and reduces virulence in mice.

bioRxiv · Aug 29, 2019 · PreprintMicrobiology