Author

L. Enjuanes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

I. Sola· 4 shared C. Wang· 2 shared D. Drabek· 2 shared F. Grosveld· 2 shared R. Fernandez-Delgado· 2 shared R. van Haperen· 2 shared W. Li· 2 shared A. D. Osterhaus· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

I. Sola

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

Y. M. Alhammad, S. Parthasarathy, R. Ghimire, J. J. O'Connor, C. M. Kerr, J. J. Pfannenstiel, D. Chanda, C. A. Miller, R. Unckless, S. Zuniga, L. Enjuanes, S. More, R. Channappanavar, A. Fehr

This study shows that SARS-CoV-2 Mac1 is essential for pathogenesis but not replication, as Mac1-deleted virus replicates normally but induces higher IFN responses and reduced disease in mice.

bioRxiv · Apr 6, 2023 · PreprintMicrobiology

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants

W. Du, D. L. Hurdiss, D. Drabek, A. Z. Mykytyn, F. Kaiser, M. Gonzalez-Hernandez, D. Munoz-Santos, M. M. Lamers, R. van Haperen, W. Li, I. Drulyte, C. Wang, I. Sola, F. Armando, G. Beythien, , B. J. Bosch

bioRxiv · Feb 17, 2022 · PreprintMicrobiology

SARS-CoV-2 Point Mutation and Deletion Spectra, and Their Association with Different Disease Outcome

B. Martinez-Gonzalez, M. E. Soria, L. Vazquez-Sirvent, C. Ferrer-Orta, R. Lobo-Vega, P. Minguez, L. De la Fuente, C. Llorens, B. Soriano, R. Ramos-Ruiz, M. Corton, R. Lopez-Rodriguez, C. Garcia-Crespo, I. Gallego, A. I. de Avila, , C. Perales

The paper analyzes SARS-CoV-2 mutant spectra from diagnostic samples and finds higher point mutation complexity in isolates from patients with mild disease compared to moderate or severe disease.

bioRxiv · Jan 10, 2022Microbiology

Reverse Genetics with a Full-length Infectious cDNA Clone of Bovine Torovirus

M. Ujike, Y. Etoh, N. Urushiyama, F. Taguchi, L. Enjuanes, W. Kamitani

This paper develops a reverse genetics system for bovine torovirus using a full-length infectious cDNA clone, demonstrating the effects of genetic manipulations on viral growth and gene stability.

bioRxiv · Oct 28, 2020 · PreprintMicrobiology

Isolation of cross-reactive monoclonal antibodies against divergent human coronaviruses that delineate a conserved and vulnerable site on the spike protein

C. Wang, R. van Haperen, J. Gutierrez-Alvarez, W. Li, N. Okba, I. Albulescu, I. Widjaja, B. van Dieren, R. Fernandez-Delgado, I. Sola, D. Hurdiss, O. Daramola, F. Grosveld, F. van Kuppeveld, B. Haagmans, , B.-J. Bosch

This study isolates two cross-reactive monoclonal antibodies against multiple Betacoronaviruses, identifying a conserved vulnerable site on the spike protein.

bioRxiv · Oct 20, 2020 · PreprintMicrobiology

Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins

J. M. Diez, C. Romero, J. Vergara Alert, M. Bello Perez, J. Rodon, J. M. Honrubia, J. Segales, I. Sola, L. Enjuanes, R. Gajardo

This study shows that currently available IVIG products neutralize SARS-CoV-2 and SARS-CoV in cell cultures but not MERS-CoV.

bioRxiv · Jun 19, 2020Immunology

The deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model

R. Knaap, R. Fernandez-Delgado, T. J. Dalebout, N. Oreshkova, P. J. Bredenbeek, L. Enjuanes, I. Sola, E. J. Snijder, M. Kikkert

This study shows that disrupting the deubiquitinating activity of MERS-CoV PLpro enhances innate immune responses and reduces virulence in mice.

bioRxiv · Aug 29, 2019 · PreprintMicrobiology