M. Mitreva

Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibility

The paper identifies IL-1 receptor antagonist as a conserved factor limiting Mtb control across mice, non-human primates, and humans.

Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry

Simple derivatives of the well-known antifungal drug fluconazole were found to be highly effective in vivo against fungal infections and potent against parasitic nematodes causing lymphatic filariasis and soil-transmitted helminths.

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small 1intestinal epithelia

This study shows that ETEC heat-labile toxin causes long-term intestinal damage beyond diarrhea, affecting nutrient absorption and growth in mice.

Differential excretory/secretory proteome of the adult female and male stages of the human blood fluke, Schistosoma mansoni

The paper identifies and compares excretory/secretory proteins from adult male and female Schistosoma mansoni worms using proteomics, revealing sex-specific functional differences.

Lung epithelial signaling mediates early vaccine-induced CD4+ T cell activation and Mtb control

This study identifies lung epithelial signaling as critical for early vaccine-induced CD4+ T cell activation and Mtb control in BCG vaccinated hosts.

IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

This study identifies transcriptional signatures of IFN signaling and neutrophil degranulation in SARS-CoV-2 infected rhesus macaques and humans, highlighting age-related differences and shared pathways with tuberculosis.

Improving characterization of understudied human microbiomes using targeted phylogenetics

The paper improves mapping of metagenomic reads from under-represented body sites by sequencing and assembling 665 new bacterial genomes, increasing read mapping rates for the Human Microbiome Project samples.

De novo identification of toxicants that cause irreparable damage to parasitic nematode intestinal cells

The paper identifies 10 inhibitors that cause irreparable damage to intestinal cells of parasitic nematodes, showing potential for broad-spectrum anthelmintics.