N. Zhu

Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana

This study shows that aliphatic aldoximes repress phenylpropanoid production and that altered methionine metabolism affects plant growth and development in Arabidopsis.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

N-MYC regulates Cell Survival via eIF4G1 in inv(16) Acute Myeloid Leukemia

The paper shows N-MYC promotes survival in inv(16) AML by regulating eIF4G1, identifying a novel MYCN enhancer and a new oncogenic role for eIF4G1 in AML.

StereoSiTE: A framework to spatially and quantitatively profile the cellular neighborhood organized iTME

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

Long Noncoding RNA MALAT1 is Dynamically Regulated in Leader Cells during Collective Cancer Invasion

The paper shows MALAT1 lncRNA is dynamically regulated in leader cells during collective cancer invasion, with its expression increasing when cells become leaders and decreasing when migration stops.

EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties

This study shows that EBV LMP1 activates mTORC1 and mTORC2 to promote cancer stem cell properties in nasopharyngeal carcinoma, with distinct roles in drug resistance, tumor initiation, and metastasis.

Transient nuclear deformation primes epigenetic state and promotes cell reprogramming

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

Nrf2 modulates the hybrid epithelial/mesenchymal phenotype and Notch signaling during collective cancer migration

This study shows Nrf2 stabilizes hybrid epithelial/mesenchymal cells and coordinates Notch signaling during collective cancer migration.

Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

Redox proteomics of stomatal immunity reveals role of a lipid transfer protein in plant defense

The study identifies redox-sensitive proteins in guard cells during stomatal immunity and characterizes a lipid transfer protein as a redox sensor in plant defense.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Epigenetic regulation of protein translation in KMT2A-rearranged AML

This paper evaluates combinations of DOT1L and EZH2 inhibitors in KMT2A-rearranged AML, finding synergistic effects with a protein translation inhibitor but not with EZH2 inhibition.