Author

P. Lara-Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:C. elegans· 4 Research Focus:development & morphogenesis· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Desai· 4 shared J. Budrewicz· 3 shared K. Oegema· 3 shared A. Deep· 2 shared J. Houston· 2 shared K. D. Corbett· 2 shared T. Kim· 2 shared A. Bellaart· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

A. Desai

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5 papers

Recent·Most cited

Phospho-KNL-1 recognition by a TPR domain targets the BUB-1/BUB-3 complex to C. elegans kinetochores

J. Houston, C. Vissotsky, A. Deep, H. Hakozaki, E. Crews, K. Oegema, K. D. Corbett, P. Lara-Gonzalez, T. Kim, A. Desai

This study shows that the BUB-1 TPR domain directly binds phosphorylated KNL-1 motifs, essential for BUB-1-BUB-3 localization and function in C. elegans.

bioRxiv · Feb 9, 2024 · PreprintCell Biology

Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses

P. Lara-Gonzalez, S. Variyar, J. Budrewicz, A. Schlientz, N. Varshney, A. Bellaart, S. Moghareh, A. C. N. Nguyen, K. Oegema, A. Desai

This study identifies cyclin B3 as the key driver of rapid mitoses in early C. elegans embryos, showing it enables faster cell division compared to cyclin B1 and B2.

bioRxiv · Aug 11, 2023 · PreprintCell Biology

PLK-1 tethered on BUB-1 directs CDC-20 kinetochore recruitment to ensure timelyembryonic mitoses

J. Houston, M. Ohta, J. S. Gomez-Cavazos, A. Deep, K. D. Corbett, K. Oegema, P. Lara-Gonzalez, T. Kim, A. Desai

This study shows that PLK-1 tethered on BUB-1 promotes CDC-20 recruitment to kinetochores, ensuring timely mitosis in C. elegans embryos through phosphoregulation.

bioRxiv · Oct 7, 2022Cell Biology

Nuclear-enriched protein phosphatase 4 ensures outer kinetochore assemblyprior to nuclear dissolution

H. Rocha, P. A. Simoes, J. Budrewicz, P. Lara-Gonzalez, A. Xavier de Carvalho, J. Dumont, A. Desai, R. Gassmann

The paper shows that PP4 ensures outer kinetochore assembly before nuclear envelope breakdown, which is critical for proper chromosome segregation.

bioRxiv · Sep 1, 2022Cell Biology

BUB-1 targets PP2A:B56 to regulates chromosome congression during meiosis I in C. elegans oocytes

L. Bel Borja, F. Soubigou, S. J. P. Taylor, C. Fraguas Bringas, J. Budrewicz, P. Lara-Gonzalez, C. G. Sorensen Turpin, J. N. Bembenek, D. K. Cheerambathur, F. Pelisch

This study identifies BUB-1 as the key factor recruiting PP2A:B56 to chromosomes during meiosis I in C. elegans oocytes, essential for proper chromosome congression.

bioRxiv · Jun 12, 2020Cell Biology