Author

L. Cocquerel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

C. Montpellier· 6 shared M. Ferrie· 5 shared M. Ankavay· 4 shared C. Camuzet· 3 shared C.-M. Aliouat-Denis· 3 shared J. Dubuisson· 3 shared K. Hervouet· 3 shared Y. Rouille· 3 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

C. Montpellier

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein

G. Joshi, E. Decembre, J. Brocard, C. Montpellier, M. Ferrie, O. Allatif, A.-K. Mehnert, J. Pons, D. Galiana, V. L. Dao Thi, N. Jouvenet, L. Cocquerel, M. Dreux

This study shows that Hepatitis E Virus (HEV) ORF2 protein modulates plasmacytoid dendritic cell (pDC)-mediated antiviral responses by affecting pDC recognition of infected cells.

bioRxiv · Apr 12, 2024Immunology

Proliferative cell targeting and epithelial cell turnover fuels hepatitis E virus replication in human intestinal enteroids

N. Santos-Ferreira, X. Zhang, L. Corneillie, J. Van Dycke, W. Chiu, C. Montpellier, J. Neyts, L. Cocquerel, S. Kaptein, J. Rocha-Pereira

This study establishes an HEV-HIE model showing HEV replication in intestinal epithelial cells, with proliferative cells being the main targets, suggesting the gut as an HEV reservoir.

bioRxiv · Mar 27, 2024Microbiology

A HEV ORF2 protein-mediated mechanism of hepatitis E associated kidney disease.

B. Helmchen, A.-L. Leblond, D. Lenggenhager, J. Jetzer, M. Ankavay, F. Helmchen, H. Yurtsever, R. Parrotta, M. E. Healy, A. Poeschel, E. Markkanen, N. Semmo, M. Ferrie, L. Cocquerel, H. Seeger, , A. Weber

This study identifies HEV ORF2 protein as a cause of glomerulonephritis in hepatitis E patients through immune complex deposition, without detectable viral particles or RNA.

bioRxiv · Sep 14, 2023 · PreprintPathology

Characterization of the hepatitis E virus replicase

K. Metzger, B. Cyrine, K. Hervouet, V. Alexandre, C. Montpellier, J. M. Saliou, M. Ferrie, C. Camuzet, Y. Rouille, C. Lecoeur, J. Dubuisson, L. Cocquerel, C. M. Aliouat Denis

This study characterizes the hepatitis E virus replicase by inserting V5 epitopes into ORF1 and identifying its localization and processing during replication.

bioRxiv · Dec 3, 2021Microbiology

The Endocytic Recycling Compartment Serves as a Viral Factory for Hepatitis E Virus

C. Bentaleb, K. Hervouet, C. Montpellier, C. Camuzet, M. Ferrie, J. Burlaud-Gaillard, S. Bressanelli, K. Metzger, E. Werkmeister, M. Ankavay, N. L. Janampa, J. Marlet, J. Roux, C. Deffaud, A. Goffard, , L. Cocquerel

This study identifies the endocytic recycling compartment as a site where HEV forms membrane networks, revealing a novel viral factory structure.

bioRxiv · Oct 14, 2021Microbiology

An Arginine-Rich Motif in the ORF2 Capsid Protein Regulates the Hepatitis E Virus Lifecycle and Interactions with the Host Cell

K. Hervouet, M. Ferrie, M. Ankavay, C. Montpellier, C. Camuzet, V. Alexandre, A. Dembele, C. Lecoeur, A. T. Foe, P. Bouquet, D. Hot, T. Vausselin, J.-M. Saliou, S. Salome-Desnoulez, L. Marsollier, , L. Cocquerel

This study identifies an Arginine-Rich Motif in the HEV ORF2 capsid protein that regulates its subcellular localization, functionality, and interactions with host cells, revealing its central role in the HEV lifecycle.

bioRxiv · May 26, 2021Microbiology

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

M. Ankavay, C. Montpellier, I. M. Sayed, J.-M. Saliou, C. Wychowski, L. Saas, S. Duvet, C.-M. Aliouat-Denis, R. Farhat, V. de Masson d'Autume, P. Meuleman, J. D. Dubuisson, L. Cocquerel

This study characterizes the glycosylation of HEV ORF2 protein and its role in viral lifecycle, showing that glycosylation does not affect particle assembly but contributes to antigenicity and nuclear translocation of ORF2i.

bioRxiv · Oct 5, 2018Microbiology