Author

J. M. Luna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

C. M. Rice· 6 shared A. F. Stenzel· 4 shared A. W. Ashbrook· 4 shared E. Michailidis· 4 shared I. Ricardo-Lax· 4 shared J. Le Pen· 4 shared W. M. Schneider· 4 shared A. Peace· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

6 shared papersImmunology

C. M. Rice

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

J. Le Pen, G. Paniccia, V. Kinast, M. Moncada-Velez, A. W. Ashbrook, M. Bauer, H.- H. Hoffmann, A. Pinharanda, I. Ricardo-Lax, A. F. Stenzel, E. A. Rosado-Olivieri, K. H. Dinnon, W. C. Doyle, C. A. Freije, S.-H. Hong, , C. M. Rice

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

bioRxiv · Feb 16, 2024Immunology

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

N. Yang, Y. Wang, S. Liu, J. M. Luna, G. Mazo, A. Y. Tan, T. Zhang, J. Wang, W. Yan, J. Choi, A. Rossi, J. Z. Xiang, C. M. Rice, T. Merghoub, J. D. Wolchok, L. Deng

bioRxiv · Oct 31, 2021 · PreprintImmunology

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

M. Kabbani, E. Michailidis, S. Steensels, C. G. Fulmer, J. M. Luna, J. Le Pen, M. Tardelli, B. Razooky, I. Ricardo-Lax, C. Zou, B. Zeck, A. F. Stenzel, C. Quirk, L. Foquet, A. W. Ashbrook, , Y. P. de Jong

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

bioRxiv · Nov 19, 2020 · PreprintPathology

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

W. M. Schneider, J. M. Luna, H.- H. Hoffmann, F. J. Sanchez-Rivera, A. A. Leal, A. W. Ashbrook, J. Le Pen, E. Michailidis, I. Ricardo-Lax, A. Peace, A. F. Stenzel, S. W. Lowe, M. R. MacDonald, C. M. Rice, J. T. Poirier

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

bioRxiv · Oct 7, 2020Microbiology

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

H.- H. Hoffmann, W. M. Schneider, F. J. Sanchez-Rivera, J. M. Luna, A. W. Ashbrook, Y. M. Soto-Feliciano, A. A. Leal, J. Le Pen, I. Ricardo-Lax, E. Michailidis, Y. Hao, A. F. Stenzel, A. Peace, C. D. Allis, S. W. Lowe, , C. M. Rice

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

bioRxiv · Sep 11, 2020Microbiology

Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against an acute vaccinia infection in the lungs

N. Yang, J. M. Luna, P. Dai, Y. Wang, C. M. Rice, L. Deng

The paper shows that lung type II alveolar epithelial cells induce IFN-beta and recruit CCR2+ monocytes to combat vaccinia virus infection.

bioRxiv · Jan 20, 2020Immunology