Author

I. M. Sayed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

S. Das· 4 shared P. Ghosh· 2 shared S.-R. Ibeawuchi· 2 shared A. Z. Sahan· 1 shared B. A. Yee· 1 shared C. Montpellier· 1 shared C. Wychowski· 1 shared C.-M. Aliouat-Denis· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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4 shared papersMicrobiology

S. Das

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Proteome profiling identifies a link between the mitochondrial pathways and host-microbial sensor ELMO1 following Salmonella infection.

S. Achi, D. McGrosso, S. Tocci, S.-R. Ibeawuchi, I. M. Sayed, D. J. Gonzalez, S. Das

This study identifies a link between ELMO1 and mitochondrial pathways in macrophages during Salmonella infection through proteome profiling and functional analysis.

bioRxiv · May 3, 2024 · PreprintMicrobiology

The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses

I. M. Sayed, S.-R. Ibeawuchi, D. Lie, M. S. Anandachar, R. Pranadinata, M. Raffatellu, S. Das

The paper investigates how WxxxE bacterial effectors interact with ELMO1 to regulate inflammation, showing that ELMO1 differentiates pathogenic from commensal bacteria and enhances inflammatory responses through these interactions.

bioRxiv · Jun 7, 2021Microbiology

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

N. Abbasi, T. Long, Y. Li, E. Ma, B. A. Yee, P. R. Patel, I. M. Sayed, N. Varki, S. Das, P. Ghosh, G. W. Yeo, W. J. M. Huang

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

bioRxiv · Mar 25, 2020Cancer Biology

NEIL2 plays a critical role in limiting inflammation and preserving genomic integrity in H. pylori-infected gastric epithelial cells

A. Z. Sahan, T. Venkova, I. M. Sayed, E. Beswick, V. Reyes, I. Pinchuk, D. Sahoo, P. Ghosh, T. K. Hazra, S. Das

This study shows that NEIL2 suppression by H. pylori infection leads to DNA damage accumulation, inflammation, and gastric cancer progression in mouse models and human cells.

bioRxiv · Jul 2, 2019 · PreprintMicrobiology

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

M. Ankavay, C. Montpellier, I. M. Sayed, J.-M. Saliou, C. Wychowski, L. Saas, S. Duvet, C.-M. Aliouat-Denis, R. Farhat, V. de Masson d'Autume, P. Meuleman, J. D. Dubuisson, L. Cocquerel

This study characterizes the glycosylation of HEV ORF2 protein and its role in viral lifecycle, showing that glycosylation does not affect particle assembly but contributes to antigenicity and nuclear translocation of ORF2i.

bioRxiv · Oct 5, 2018Microbiology