Inhibition of host Lactate dehydrogenase A by a small-molecule limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid
G. Krishnamoorthy, P. Kaiser, U. Abu Abed, J. Weiner, P. Moura-Alves, V. Brinkmann, S. H. E. Kaufmann
This paper shows that inhibiting host LDHA with FX11 limits M. tuberculosis growth and enhances the effectiveness of isoniazid in a mouse model of TB.
bioRxiv · May 7, 2019 · PreprintMicrobiology