V. Brinkmann

Identification of a specific granular marker of zebrafish eosinophils enables development of new tools for their study

The paper identifies a specific marker for zebrafish eosinophils and develops new tools to study their biology and function in disease.

MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in Drosophila gut during inflammation

This study shows that MprF in Lactiplantibacillus plantarum helps it survive in Drosophila gut during inflammation by reducing immune response and maintaining microbial stability.

Generation of a Plasmodium falciparum reporter line for studies of parasite biology throughout the life cycle

This paper generates a new fluorescent reporter parasite strain, PfOBC13GFP, for studying Plasmodium falciparum throughout its life cycle with improved fluorescence and mosquito infectivity.

Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila

This study identifies mechanisms by which gut commensals resist host antimicrobial peptides during infection and aging in Drosophila.

Chlamydia coinfection inhibits HPV-induced safeguards of the cellular and genomic integrity in patient-derived ectocervical organoids

This study shows that Chlamydia coinfection with HPV disrupts cellular and genomic integrity safeguards in ectocervical organoids, promoting neoplastic progression.

Histone H3 Clipping is a novel signature of Human Neutrophil Extracellular Traps

This study identifies a histone H3 cleavage event specific to neutrophil extracellular traps (NETs) and develops an antibody to detect and quantify NETs in various samples.

Ahr-bacterial diet interaction modulates aging and associated pathologies in C. elegans

This paper shows that C. elegans AHR-1 modulates aging and age-related pathologies through interactions with bacterial diet metabolites, establishing C. elegans as a model for studying AhR functions.

Inhibition of host Lactate dehydrogenase A by a small-molecule limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid

This paper shows that inhibiting host LDHA with FX11 limits M. tuberculosis growth and enhances the effectiveness of isoniazid in a mouse model of TB.

Transition of Wnt signaling microenvironment delineates the squamo-columnar junction and emergence of squamous metaplasia of the cervix

The paper identifies that Wnt signaling dynamics in the stroma regulate the squamo-columnar junction and the emergence of squamous metaplasia in the cervix, without a localized stem cell population at the boundary.

Unbiased classification of mosquito blood cells by single-cell genomics and high-content imaging

The paper uses single-cell genomics and imaging to classify mosquito blood cells, revealing transcriptional signatures and challenges to current morphology-based classification.

Non-competitive resource exploitation within-mosquito shapes evolution of malaria virulence

This study shows that mosquito lipid trafficking affects Plasmodium virulence by shaping sporozoite development and metabolic activity, revealing a vector-driven mechanism in malaria virulence evolution.