Author

P. R. Patel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 6 Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 7 Assay:electrophysiology· 5 Organism:mouse· 4 Organism:rat· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. A. Chestek· 6 shared J. M. Richie· 5 shared E. J. Welle· 4 shared W. J. M. Huang· 4 shared N. Chen· 3 shared S. Ma· 3 shared Y. Li· 3 shared A. A. Jiman· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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6 shared papersBioengineering

C. A. Chestek

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Utah Array Characterization and Histological Analysis of a Multi-Year Implant in Non-Human Primate Motor and Sensory Cortices

P. R. Patel, E. J. Welle, J. G. Letner, H. Shen, A. J. Bullard, C. M. Caldwell, J. M. Richie, H. E. Thayer, P. G. Patil, D. Cai, C. A. Chestek

The paper characterizes the histological and material changes in a non-human primate brain after long-term Utah array implantation, finding significant neuron loss and electrode damage.

bioRxiv · Aug 27, 2022Bioengineering

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

T. Dong, L. Chen, P. R. Patel, J. M. Richie, C. A. Chestek, A. J. Shih

This paper introduces a machine for automated assembly of high-density carbon fiber electrode arrays, achieving precise placement and demonstrating successful single unit electrophysiological recordings in rats.

bioRxiv · Aug 17, 2022Bioengineering

LncRNA Malat1 represses Th17 effector program by maintaining a critical bivalent super-enhancer and promotes intestinal inflammation

S. Ma, B. Zhou, Y. Abe, N. Chen, C. Luo, Y. Li, P. R. Patel, A. Zheng, S. A. Patel, Y. Hao, J. T. Chang, X. Fu, W. J. M. Huang

This study shows that lncRNA Malat1 restricts Th17 cell IL-17A production by regulating a bivalent super-enhancer, thereby controlling intestinal inflammation resolution.

bioRxiv · Mar 21, 2022 · PreprintImmunology

RORγt serine 182 tightly regulates T cell heterogeneity to maintain mucosal homeostasis and restrict tissue inflammation

S. Ma, S. Patel, N. Chen, P. R. Patel, B. S. Cho, N. Abbasi, J. T. Chang, W. J. M. Huang

This study shows that RORγt serine 182 regulates T cell heterogeneity in the intestine, maintaining homeostasis and limiting inflammation.

bioRxiv · May 14, 2021 · PreprintImmunology

Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

J. M. Richie, P. R. Patel, E. J. Welle, T. Dong, L. Chen, A. J. Shih, C. A. Chestek

This paper describes a low-cost, benchtop method for fabricating carbon fiber microelectrode arrays with improved tip optimization techniques.

bioRxiv · Mar 22, 2021 · PreprintBioengineering

Sharpened and mechanically durable carbon fiber electrode arrays for neural interfacing

E. J. Welle, J. E. Woods, A. A. Jiman, J. M. Richie, E. C. Bottorff, Z. Ouyang, J. P. Seymour, P. R. Patel, T. M. Bruns, C. A. Chestek

This paper develops durable carbon fiber electrode arrays for precise neural recording in rat and feline tissues, demonstrating their effectiveness in capturing neural signals from various structures.

bioRxiv · Jan 21, 2021Bioengineering

ADAR2 deaminase activity promotes Th17 effector function and protects against intestine inflammation

S. Ma, Y. Hao, B. S. Cho, N. Chen, A. Zheng, S. Zhang, G. Sun, P. R. Patel, Y. Li, B. A. Yee, G. W. Yeo, B. Zhou, X.-D. Fu, W. J. M. Huang

This study shows ADAR2 promotes Th17 effector function by editing Malt1, leading to increased IL-17A and protection against intestinal inflammation.

bioRxiv · Sep 22, 2020 · PreprintImmunology

Cellular-scale silicon probes for high-density, precisely-localized neurophysiology

D. Egert, J. R. Pettibone, S. Lemke, P. R. Patel, C. M. Caldwell, D. Cai, K. Ganguly, C. A. Chestek, J. Berke

This paper introduces cellular-scale silicon probes for high-density neurophysiology recording in rats, demonstrating long-term stability and precise spatial registration.

bioRxiv · May 26, 2020Bioengineering

Multi-channel intraneural vagus nerve recordings with a novel high-density carbon fiber microelectrode array

A. A. Jiman, D. C. Ratze, E. J. Welle, P. R. Patel, J. M. Richie, E. C. Bottorff, J. P. Seymour, C. A. Chestek, T. M. Bruns

This study develops a high-density carbon fiber microelectrode array for recording action potentials from small autonomic nerves in rats, demonstrating its effectiveness in measuring signal amplitudes, conduction velocities, and firing rate changes.

bioRxiv · May 15, 2020Bioengineering

DDX5 targets tissue-specific RNAs to promote intestine tumorigenesis

N. Abbasi, T. Long, Y. Li, E. Ma, B. A. Yee, P. R. Patel, I. M. Sayed, N. Varki, S. Das, P. Ghosh, G. W. Yeo, W. J. M. Huang

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

bioRxiv · Mar 25, 2020Cancer Biology